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EDT - Electron Density Topography

About EDT

EDT is the integration of accurate and precise solution scattering measurements up to the middle angle region, electron density calculations utilizing DENSS [1, 2] and intelligent routines for evaluation of self-consistency of the data and results, including a machine learning process for classification of results to cope with the many-solution and many-body problems in the process [3]. 

mAb molecule visualizationElectron density of a monoclonal antibody revealed by EDT

 

Publications and resources

  1. Grant, T. D. (2018). Ab initio electron density determination directly from solution scattering data. Nature Methods, 15(3), 191-193. (https://doi.org/10.1038/nmeth.4581)
  2. Grant, T. D. (2022). Reconstruction of 3D density from solution scattering. Methods in Enzymology, Volume 678, 145-186. (https://doi.org/10.1016%2Fbs.mie.2022.09.018) 
  3. Takashi M., Akihito Y., Takashi S. (2023). 3D molecular visualization of a human antibody by MAXS measurement reveals significant differences between the solution and crystalline states. Rigaku Journal, 39(1).

Our presentations

  • Dec 2024: Antibody Engineering & Therapeutics, San Diego, USA
  • Dec 2024: The Antibody Society of Japan, Sendai, Japan
  • Nov 2024: Protein Sciences in Drug Discovery, Cambridgeshire, UK
  • Nov 2024: Japanese Biochemical Society, Yokohama, Japan
  • Nov 2024: Protein Structure Determination in Industry, Paris, France
  • Oct 2024: Chem-Bio Informatics Society, Tokyo, Japan
  • Oct 2024: Antibody Engineering & Therapeutics Asia, Kyoto, Japan
  • Sep 2024: The Society for Biotechnology, Tokyo, Japan
  • Sep 2024: CASSS/Higher Order Structure Symposium, Rockville, USA
  • Jun 2024: The Protein Society, Vancouver, Canada
  • Jun 2024: Protein Science Society of Japan, Sapporo, Japan
  • Mar 2024: Pharmaceutical Society of Japan, Yokohama, Japan
  • Dec 2023: Antibody Engineering & Therapeutics, San Diego, USA
  • Dec 2023: The Antibody Society of Japan, Kagoshima, Japan
  • Oct 2023: Antibody Engineering & Therapeutics Digital week
  • Sep 2023: The Society for Biotechnology, Nagoya, Japan
  • May 2023: Antibody Engineering & Therapeutics Digital week
  • Mar 2023: Bispecific Antibodies Asia & Pacific